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Both. A link between Epa adhesins and the colon mucosa has been demonstrated by showing adhesion of Saccharomyces cerevisiae cells expressing Epa1p and Epa6p to human colorectal carcinoma (Caco-2) cells (28). A connection between the Epa proteins and CD43 (leukosialin)/CD45 (receptor-type tyrosine-protein phosphatase C) is also present in the LGI network (Fig. 4), and this is justified by the pres

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