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Enhancer of the Kinase Suppressor of Ras-1), a regulator and binding partner of KSR1, is another scaffolding protein which is less understood. Its role in pancreatic cancer biology, or as a biomarker, remains to be explored. Current data suggests that CNKSR1 has multiple roles cancer biology, with some reports demonstrating that CNKSR1 interacts with tumor suppressors and othersdescribe its scaffo
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Ells stained [24, 25]. CNKSR1 expression was evaluated based on intensity semiquantitatively on a four-tier scale (0 = negative, 1 = weak/background, 2 = moderate/positive, 3 = strongly positive). CNKSRshows minimal expression in lymphoid tissues according to RNA-Seq data and immunohistochemical staining from the Human Protein Atlas (Human Protein Atlas available from www.proteinatlas.org) [26]. S
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Ells stained [24, 25]. CNKSR1 expression was evaluated based on intensity semiquantitatively on a four-tier scale (0 = negative, 1 = weak/background, 2 = moderate/positive, 3 = strongly positive). CNKSRshows minimal expression in lymphoid tissues according to RNA-Seq data and immunohistochemical staining from the Human Protein Atlas (Human Protein Atlas available from www.proteinatlas.org) [26]. S
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A, c ?200; b, d ?Quadri et al. BMC Cancer (2017) 17:Page 5 ofFig. 3 Photomicrographs of pancreatic cancer tissue microarray (TMA) cores of p-ERK immunohistochemical staining: a no staining for p-ERK (score 0); b weak p-ERK (score 1+) staining; c moderate p-ERK (score 2+) staining; d strong p-ERK (score 3+) staining. Magnification: a-d: ?70 cases as 2+ (58.3 ), and 16 cases as 3+ (13.3 ) (Fig. 5a).
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A, c ?200; b, d ?Quadri et al. BMC Cancer (2017) 17:Page 5 ofFig. 3 Photomicrographs of pancreatic cancer tissue microarray (TMA) cores of p-ERK immunohistochemical staining: a no staining for p-ERK (score 0); b weak p-ERK (score 1+) staining; c moderate p-ERK (score 2+) staining; d strong p-ERK (score 3+) staining. Magnification: a-d: ?70 cases as 2+ (58.3 ), and 16 cases as 3+ (13.3 ) (Fig. 5a).
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E inflammatory response and tissue remodeling in tendon healing and also it revealed that; although the severe inflammatory reaction has been developed in response to the collagen implant, but this immune response was due to the remodeling effect of the collagen implant, not its rejection. It has been postulated that inflammation has a major role in tendon healing and if immune response does not p
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E inflammatory response and tissue remodeling in tendon healing and also it revealed that; although the severe inflammatory reaction has been developed in response to the collagen implant, but this immune response was due to the remodeling effect of the collagen implant, not its rejection. It has been postulated that inflammation has a major role in tendon healing and if immune response does not p
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Ning (no staining for p-ERK (score 0); weak p-ERK (score 1+), moderate p-ERK (score 2+), and strong p-ERK (score 3 +) staining) in Fig. 3. Staining intensities were grouped as dichotomous variables, defining scores 0? as low and 2? as high expression levels [25]. Evaluation of staining was carried out independently by two pathologists (MM and MA) blinded to patients' outcome and pathological stage